Sexual adverse effects can occur in up to 10% of menĮrectile dysfunction, ejaculation disorders, decreased libido, and breast tenderness and swelling can occur in up to 6% of men taking dutasteride alone and 10% of men taking dutasteride with tamsulosin.Combination therapy is more effective than an alpha blocker aloneĭutasteride with tamsulosin is significantly more effective than tamsulosin monotherapy in reducing prostate size, improving symptoms and urinary flow, and reducing the incidence of urinary retention and prostate surgery.Tamsulosin and other alpha blockers provide rapid symptom relief but do not reduce prostate size. Alpha blockers provide rapid symptom relief.Dutasteride reduces prostate size and prevents disease progressionĬompared with placebo, dutasteride significantly reduces prostate volume, improves symptoms and urinary flow, and reduces the incidence of urinary retention and prostate surgery.Under the listing it must be prescribed with an alpha blocker, with treatment initiated by a urologist. Dutasteride - a 5-alpha reductase inhibitor (5-ARI)ĭutasteride is PBS listed for treating lower urinary tract symptoms (LUTS) due to benign prostatic hyperplasia (BPH).
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